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Biochem Soc Trans. 2004 Dec;32(Pt 6):918-9.

HMGN proteins play roles in DNA repair and gene expression in mammalian cells.

Author information

1
Division of Cancer Sciences and Molecular Pathology, Western Infirmary (Pathology), University of Glasgow, Dumbarton Road, Glasgow G11 6NT, UK. k.west@clinmed.gla.ac.uk

Abstract

HMGN (high-mobility-group N) family members are vertebrate proteins that unfold chromatin and promote transcription and replication of chromatin templates in vitro. However, their precise roles in vivo have been elusive until recently. This paper summarizes recent advances from studies of Hmgn1 knockout mice and genetically engineered cell lines that are beginning to reveal the diverse roles that HMGN proteins play in DNA repair and transcription within mammalian cells.

PMID:
15506924
DOI:
10.1042/BST0320918
[Indexed for MEDLINE]

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