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Neuropsychology. 2004 Oct;18(4):629-37.

Neuropsychological correlates of diffusion tensor imaging in schizophrenia.

Author information

1
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston Veterans Affairs Health Care System-Brockton Division, Brockton, MA 02301, USA. paul.nestor@umb.edu.

Abstract

Patients with schizophrenia (n = 41) and healthy comparison participants (n = 46) completed neuropsychological measures of intelligence, memory, and executive function. A subset of each group also completed magnetic resonance diffusion tensor imaging (DTI) studies (fractional anisotropy and cross-sectional area) of the uncinate fasciculus (UF) and cingulate bundle (CB). Patients with schizophrenia showed reduced levels of functioning across all neuropsychological measures. In addition, selective neuropsychological-DTI relationships emerged. Among patients but not controls, lower levels of declarative-episodic verbal memory correlated with reduced left UF, whereas executive function errors related to performance monitoring correlated with reduced left CB. The data suggested abnormal DTI patterns linking declarative-episodic verbal memory deficits to the left UF and executive function deficits to the left CB among patients with schizophrenia.

PMID:
15506830
PMCID:
PMC2790923
DOI:
10.1037/0894-4105.18.4.629
[Indexed for MEDLINE]
Free PMC Article
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