Format

Send to

Choose Destination
J Cell Biol. 2004 Oct 25;167(2):193-5.

Cell differentiation: reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins.

Author information

1
Department of Neuroscience, Uppsala University, Biomedical Centre, S-751 23 Uppsala, Sweden. Dan.Lindholm@neuro.uu.se

Abstract

The molecular mechanisms by which differentiated cells combat cell death and injury have remained unclear. In the current issue, it has been shown in neurons that cell differentiation is accompanied by a decrease in Apaf-1 and the activity of the apoptosome with an increased ability of the inhibitor of apoptosis proteins (IAPs) to sustain survival (Wright et al., 2004). These results, together with earlier ones, deepen our understanding of how cell death and the apoptosome are regulated during differentiation and in tumor cells.

PMID:
15504905
PMCID:
PMC2172544
DOI:
10.1083/jcb.200409171
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center