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Nat Med. 2004 Nov;10(11):1190-2. Epub 2004 Oct 24.

Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.

Author information

1
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.

Abstract

The Arctic mutation within the amyloid-beta (Abeta) peptide causes Alzheimer disease. In vitro, Arctic-mutant Abeta forms (proto)fibrils more effectively than wild-type Abeta. We generated transgenic mouse lines expressing Arctic-mutant human amyloid precursor proteins (hAPP). Amyloid plaques formed faster and were more extensive in Arctic mice than in hAPP mice expressing wild-type Abeta, even though Arctic mice had lower Abeta(1-42/1-40) ratios. Thus, the Arctic mutation is highly amyloidogenic in vivo.

PMID:
15502844
DOI:
10.1038/nm1123
[Indexed for MEDLINE]

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