A synthetic polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate), stimulates insulin release from RINm5F insulinoma cells

Susumu Maruyama; Jianen Hu; Akiko Yamanaka; Toshiaki Ichimura

doi:10.1271/bbb.68.2197

A synthetic polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate), stimulates insulin release from RINm5F insulinoma cells

Biosci Biotechnol Biochem. 2004 Oct;68(10):2197-200. doi: 10.1271/bbb.68.2197.

Authors

Susumu Maruyama¹, Jianen Hu, Akiko Yamanaka, Toshiaki Ichimura

Affiliation

¹ Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8566, Japan. s-maruyama@aist.go.jp

PMID: 15502370
DOI: 10.1271/bbb.68.2197

Abstract

A water-soluble phospholipid-like polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate) (PMC(18), average molecular weight = 4.3 x 10(4)), at a concentration (0.5-5 mg/ml) showing no inhibition of cell proliferation, stimulated insulin release from RINm5F rat insulinoma cells in a concentration- and time-related manner. But poly(2-methacryloyloxyethyl phosphorylcholine) and other synthetic phospholipid-like polymers failed to stimulate insulin release.

MeSH terms

Animals
Cell Proliferation / drug effects
Exocytosis / drug effects*
Exocytosis / physiology
Insulin / metabolism*
Insulin Secretion
Insulinoma / metabolism*
Methacrylates / pharmacology*
Pancreatic Neoplasms / metabolism*
Phosphorylcholine / analogs & derivatives*
Phosphorylcholine / pharmacology*
Polymethacrylic Acids
Rats
Tumor Cells, Cultured

Substances

Insulin
Methacrylates
Polymethacrylic Acids
poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate)
poly(2-methacryloyloxyethyl-phosphorylcholine)
Phosphorylcholine