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Exp Cell Res. 2004 Nov 15;301(1):38-42.

New insights into the structural organization of eukaryotic and prokaryotic cytoskeletons using cryo-electron tomography.

Author information

1
Department of Structural Biology, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany.

Abstract

Cryo-electron tomography (cryo-ET) is an emerging imaging technology that combines the potential of three-dimensional (3-D) imaging at molecular resolution (<5 nm) with a close-to-life preservation of the specimen. In conjunction with pattern recognition techniques, it enables us to map the molecular landscape inside cells. The application of cryo-ET to intact cells provides novel insights into the structure and the spatial organization of the cytoskeleton in prokaryotic and eukaryotic cells.

PMID:
15501443
DOI:
10.1016/j.yexcr.2004.08.005
[Indexed for MEDLINE]

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