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Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12.

Synthesis of small molecule CDC25 phosphatases inhibitors.

Author information

1
Ipsen Research Laboratories, Institut Henri Beaufour, 5, Avenue du Canada, F-91966 Les Ulis Cédex, France. m-odile.galcera.contour@ipsen.com

Abstract

A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target.

PMID:
15501045
DOI:
10.1016/j.bmcl.2004.09.041
[Indexed for MEDLINE]

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