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Cancer Lett. 2004 Dec 8;216(1):109-14.

High expression of endothelial cell nitric oxide synthase in peritumoral microvessels predicts increased disease-free survival in colorectal cancer.

Author information

1
Division of Cell Biology, Department of Anatomy and Physiology, KVL, Gronnegaardsvej 7, Dk-1870 Frederiksberg C/Copenhagen, Denmark.

Abstract

We have previously shown that a high frequency of microvessels expressing endothelial cell nitric oxide synthase (ecNOS) in the area surrounding the primary tumor (peritumoral ecNOS-expressing microvessel density: PEMVD) is a favorable prognostic indicator in breast cancer. Studies of a retrospective material of 186 colorectal tumors (Duke's stage B) now show that PEMVD is a significant and independent prognostic indicator for disease-free survival also in these patients. These data reinforce our hypothesis that a high level of expression of ecNOS in microvessels in the tumor-adjacent area protects against tumor metastasis.

PMID:
15500954
DOI:
10.1016/j.canlet.2004.05.025
[Indexed for MEDLINE]

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