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J Infect Dis. 2004 Nov 15;190(10):1889-92. Epub 2004 Oct 18.

Early plasmacytoid dendritic cell changes predict plasma HIV load rebound during primary infection.

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1
Département de Maladies Infectieuses et Tropicales, Hôpital St. Antoine, Assistance Publique--Hopitaux de Paris, Universite Paris VI, Paris, France.

Abstract

During human immunodeficiency virus (HIV) infection, interruption of highly active antiretroviral therapy (HAART) is usually followed by virus load rebound. Previous data have suggested a role for plasmacytoid dendritic cells (pDCs) in anti-HIV innate immunity. Here, the number of pDCs was measured by flow cytometry before, during, and after receipt of HAART in 7 patients with documented primary HIV-1 infection. A negative correlation was evidenced between pDC counts after 1 month of HAART and mean plasma virus load after interruption of HAART (r2=0.85; Spearman's partial rho =-0.92; P=.03). pDC counts during treatment might help predict immune replication control after interruption of HAART.

PMID:
15499547
DOI:
10.1086/425020
[Indexed for MEDLINE]
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