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Zhonghua Fu Chan Ke Za Zhi. 2004 Sep;39(9):606-8.

[Effects of Spasfon on course of labor].

[Article in Chinese]

Author information

1
Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital University of Medical Science, Beijing 100025, China.

Abstract

OBJECTIVE:

To observe the effects of Spasfon on improving dilatation of cervix and promoting the progression of labor.

METHODS:

Ninety seven normal primiparae with cervical edema were randomly divided into Spasfon group (group A, n = 46) and atropine group (group B, n = 51) when the cervix dilated 2 - 3 cm. Group A was given 80 mg of Spasfon intravenously, and group B was injected atropine 0.5 mg into the cervix.

RESULTS:

(1) The mean time period from drug administration to full dilation of the cervix was (3.1 +/- 0.3) h in group A, and (4.4 +/- 0.4) h in group B (P < 0.01). (2) The disappearance ratio of cervical edema 2 h after drug administration in group A was 95.6%, while in group B it was 90.2% (P > 0.05); the mean dilatation of cervix between the 2 hours in group A was (4.3 +/- 0.2) cm, while in group B it was (2.5 +/- 0.3) cm (P < 0.01). (3) There were no obvious side effects in group A. While eight women in group B complained of thirst and 22 women had increased heart rate accompanied with elevated baseline FHR, which all recovered in about 60 minutes. (4) Vaginal delivery rate in group A was 95.7%, and 90.2% in group B (P > 0.05). (5) There was no statistically significant difference in the color of amniotic fluid, suffocation state and weight of the newborns between the two groups (P > 0.05). (6) There was no statistically significant difference in postpartum hemorrhage between the two groups, either (P > 0.05).

CONCLUSION:

Spasfon can effectively improve cervical dilatation during labor and it is well tolerated by both mother and newborn.

PMID:
15498188
[Indexed for MEDLINE]
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