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Emerg Infect Dis. 2004 Sep;10(9):1550-7.

Viral loads in clinical specimens and SARS manifestations.

Author information

1
Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region, China.

Abstract

A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.

PMID:
15498155
PMCID:
PMC3320271
DOI:
10.3201/eid1009.040058
[Indexed for MEDLINE]
Free PMC Article

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