Format

Send to

Choose Destination
J Nat Prod. 2004 Oct;67(10):1716-8.

Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.

Author information

1
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA.

Abstract

Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2'-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.

PMID:
15497946
DOI:
10.1021/np049849+
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center