Steroids and sesquiterpenoids from the soft corals Dendronephthya gigantea and Lemnalia cervicorni

Chang-Yih Duh; Ali A H El-Gamal; Pei-Ying Song; Shang-Kwei Wang; Chang-Feng Dai

doi:10.1021/np030550l

Steroids and sesquiterpenoids from the soft corals Dendronephthya gigantea and Lemnalia cervicorni

J Nat Prod. 2004 Oct;67(10):1650-3. doi: 10.1021/np030550l.

Authors

Chang-Yih Duh¹, Ali A H El-Gamal, Pei-Ying Song, Shang-Kwei Wang, Chang-Feng Dai

Affiliation

¹ Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China. yihduh@mail.nsysu.edu.tw

PMID: 15497934
DOI: 10.1021/np030550l

Abstract

One new cytotoxic steroid, dendronesterone A (1), two new steroids, dendronesterones B and C (2 and 3), and a known steroid (4) were isolated from the methylene chloride solubles of the Formosan soft coral Dendronephthya gigantea. Two cytotoxic ylangene-type sesquiterpenoids, lemnalol (5) and the new compound cervicol (6), as well as two ylangene-type sesquiterpenoids, isolemnalol (7) (a new compound) and 4-oxo-alpha-ylangene (8), were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia cervicorni. Their structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
HT29 Cells
Humans
Leukemia P388
Mice
Mice, Inbred DBA
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oceans and Seas
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
Steroids / chemistry
Steroids / isolation & purification*
Steroids / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Sesquiterpenes
Steroids
dendronesterone A
dendronesterone B
dendronesterone C
lemnalol