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J Perinatol. 2005 Feb;25(2):86-9.

Follow-up of infants exposed to hydroxychloroquine given to mothers during pregnancy and lactation.

Author information

1
Division of Neonatology and NICU (M.M., A.M., G.C.), Spedali Civili - Brescia, Italy.

Abstract

OBJECTIVE:

To determine the effect of hydroxychloroquine treatment during pregnancy and lactation on babies of mothers affected by rheumatic diseases.

STUDY DESIGN AND METHODS:

A total of 40 infants born from mothers affected by rheumatic diseases and treated with hydroxychloroquine during pregnancy were enrolled in a prospective observational study. Main outcome measures at birth were incidence of prematurity, congenital malformations and neonatal infections. Of these babies, including 13 who were breast-fed, 24 were followed up during early infancy for visual function and neurodevelopmental outcome.

RESULTS:

Preterm delivery was the main complication (20.5%). No significant congenital malformations or neonatal infections were detected. All infants, including those who were breast-fed, had normal visual function and neurodevelopmental outcome.

CONCLUSIONS:

Hydroxychloroquine treatment during gestation and lactation appeared to be safe. The relatively high incidence of preterm deliveries may reflect the maternal disease state.

PMID:
15496869
DOI:
10.1038/sj.jp.7211208
[Indexed for MEDLINE]
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