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Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15760-5. Epub 2004 Oct 20.

A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development.

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1
Department of Physics, University of California, Berkeley, CA 94720, USA.

Abstract

During development, Myxococcus xanthus cells produce a series of spatial patterns by coordinating their motion through a contact-dependent signal, the C-signal. C-signaling modulates the frequency at which cells reverse their gliding direction. It does this by interacting with the Frz system (a homolog of the Escherichia coli chemosensory system) via a cascade of covalent modifications. Here we show that introducing a negative feedback into this cascade results in oscillatory behavior of the signaling circuit. The model explains several aspects of M. xanthus behavior during development, including the nonrandom distribution of reversal times, and the differences in response of the reversal frequency to both moderate and high levels of C-signaling at different developmental stages. We also propose experiments to test the model.

PMID:
15496464
PMCID:
PMC524859
DOI:
10.1073/pnas.0407111101
[Indexed for MEDLINE]
Free PMC Article
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