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Mol Biol Cell. 2005 Jan;16(1):193-201. Epub 2004 Oct 20.

Anillin binds nonmuscle myosin II and regulates the contractile ring.

Author information

1
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. astraight@stanford.edu

Abstract

We demonstrate that the contractile ring protein anillin interacts directly with nonmuscle myosin II and that this interaction is regulated by myosin light chain phosphorylation. We show that despite their interaction, anillin and myosin II are independently targeted to the contractile ring. Depletion of anillin in Drosophila or human cultured cells results in cytokinesis failure. Human cells depleted for anillin fail to properly regulate contraction by myosin II late in cytokinesis and fail in abscission. We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis.

PMID:
15496454
PMCID:
PMC539163
DOI:
10.1091/mbc.e04-08-0758
[Indexed for MEDLINE]
Free PMC Article

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