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Biochem Soc Trans. 2004 Nov;32(Pt 5):865-7.

Amylin receptors: molecular composition and pharmacology.

Author information

1
School of Biological Sciences, University of Auckland, Symonds Street, Auckland, New Zealand. dl.hay@auckland.ac.nz

Abstract

Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY(1(a)), AMY(2(a)) and AMY(3(a)) in accordance with the association of the CT receptor (CT((a))) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed.

PMID:
15494035
DOI:
10.1042/BST0320865
[Indexed for MEDLINE]

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