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J Am Chem Soc. 2004 Oct 27;126(42):13594-5.

An organometallic inhibitor for glycogen synthase kinase 3.

Author information

1
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, USA.

Abstract

Replacing natural products with kinetically inert metal complexes may lead to a new class of therapeutics in which a metal center plays the role of an innocent bystander, organizing the orientation of the organic ligands in the receptor space. As an example of this approach, a ruthenium complex is described that copies the binding mode of indolocarbazole protein kinase inhibitors and serves as a reversible, low-nanomolar inhibitor for glycogen synthase kinase 3 (GSK-3).

PMID:
15493898
DOI:
10.1021/ja046049c
[Indexed for MEDLINE]

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