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Curr Opin Plant Biol. 2004 Dec;7(6):677-86.

Cullin-containing E3 ubiquitin ligases in plant development.

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Centre for Plant Molecular Biology, Developmental Genetics, Auf der Morgenstelle 5, 72076 Tübingen, Germany.


In eukaryotes, the ubiquitin-proteasome system participates in the control of signal transduction events by selectively eliminating regulatory proteins. E3 ubiquitin ligases specifically bind degradation substrates and mediate their poly-ubiquitylation, a prerequisite for their degradation by the 26S proteasome. On the basis of the analysis of the Arabidopsis genome sequence, it is predicted that there are more than 1000 E3 ubiquitin ligases in plants. Several types of E3 ubiquitin ligases have already been characterized in eukaryotes. Recently, some of these E3 enzymes have been implicated in specific plant signaling pathways.

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