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Br J Haematol. 2004 Nov;127(3):322-5.

Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation.

Author information

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. nicholas_haining@dfci.harvard.edu

Abstract

Quantitative assessment of immunogen-specific T cell responses may provide a meaningful surrogate marker of functional immunity in patients following haemopoietic stem cell transplantation (HSCT). We developed a flow-cytometric assay to quantify antigen-specific T cell immunity to influenza-A and studied the T cell response to influenza vaccination in five children, 3-21 months post-HSCT. All patients showed an increase in influenza-A-specific CD4(+) immunity following vaccination while none had a detectable IgG response to the vaccine. This assay proved sufficiently sensitive to evaluate changes in T cell memory in immunocompromised individuals and could be used to better characterize post-HSCT immune reconstitution.

PMID:
15491293
PMCID:
PMC4516023
DOI:
10.1111/j.1365-2141.2004.05204.x
[PubMed - indexed for MEDLINE]
Free PMC Article
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