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Biochemistry. 2004 Oct 26;43(42):13233-41.

LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA.

Author information

1
Nucleic Acid Center, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense. b.vester@bmb.sdu.dk

Abstract

Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar conformation. LNA oligonucleotides display unprecedented hybridization affinity toward complementary single-stranded RNA and complementary single- or double-stranded DNA. Structural studies have shown that LNA oligonucleotides induce A-type (RNA-like) duplex conformations. The wide applicability of LNA oligonucleotides for gene silencing and their use for research and diagnostic purposes are documented in a number of recent reports, some of which are described herein.

PMID:
15491130
DOI:
10.1021/bi0485732
[Indexed for MEDLINE]

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