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Oncogene. 2004 Dec 9;23(57):9230-7.

Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase.

Author information

1
Department of Pharmacology, H078, Penn State College of Medicine, 500 University Drive Hershey, PA 17033, USA.

Abstract

Protein palmitoyltransferases (PATs) represent an exciting new target for anticancer drug design due to their pivotal roles in the subcellular localization of a number of oncogenes. We show that the Huntingtin interacting protein 14 (HIP14) is a PAT with a preference for the farnesyl-dependent palmitoylation motif found in H- and N-RAS. Characterization of HIP14 in mouse cells has revealed that it has the ability to induce colony formation in cell culture, anchorage-independent growth, and tumors in mice. Activity of the enzyme and its ability to transform cells is dependent on critical residues in the active site of the enzyme.

PMID:
15489887
PMCID:
PMC2908390
DOI:
10.1038/sj.onc.1208171
[Indexed for MEDLINE]
Free PMC Article

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