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Nutr Cancer. 2004;49(2):170-3.

Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats.

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Research Center, Tamanoi Vinegar, Co., Ltd., Nara, Japan.


The modifying effects of administering an ethyl acetate extract of Kurosu (EK), a vinegar made from unpolished rice, in drinking water on the development of azoxymethane (AOM)-induced colon carcinogenesis were investigated in male F344 rats. Animals were given 2 weekly subcutaneous injections of AOM (20 mg/kg body weight). They also received drinking water containing 0%, 0.05%, or 0.1% EK for 35 wk, starting 1 wk after the last dosing of AOM. EK administration significantly inhibited the incidence and multiplicity of colon adenocarcinoma (P < 0.05), compared with those in the AOM alone group. These findings suggest that EK may be effective for inhibiting colon carcinogenesis.

[Indexed for MEDLINE]

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