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Annu Rev Microbiol. 2004;58:587-610.

Molecular determinants of Listeria monocytogenes virulence.

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  • 1Unité des Interactions Bactéries-Cellules, Institut Pasteur, INSERM U604, 75015 Paris, France.


Listeria monocytogenes is the etiological agent of listeriosis, a severe human foodborne infection characterized by gastroenteritis, meningitis, encephalitis, abortions, and perinatal infections. This gram-positive bacterium is a facultative intracellular pathogen that induces its own uptake into nonphagocytic cells and spreads from cell to cell using an actin-based motility process. This review covers both well-established and recent advances in the characterization of L. monocytogenes virulence determinants and their role in the pathophysiology of listeriosis.

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