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Clin Infect Dis. 2004 Oct 15;39(8):1241-4. Epub 2004 Sep 23.

Adverse reactions to voriconazole.

Author information

1
Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester, United Kingdom.

Abstract

Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable--more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high voriconazole concentrations. Measurement of plasma concentrations could be helpful in optimizing voriconazole dosages.

PMID:
15486850
DOI:
10.1086/424662
[Indexed for MEDLINE]

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