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Am J Hum Genet. 2004 Dec;75(6):1143-8. Epub 2004 Oct 14.

A combined linkage-physical map of the human genome.

Author information

1
Department of Genetics, Rutgers University, Piscataway, NJ 08840, USA.

Erratum in

  • Am J Hum Genet. 2005 Feb;76(2):373.

Abstract

We have constructed de novo a high-resolution genetic map that includes the largest set, to our knowledge, of polymorphic markers (N=14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE pedigrees; that incorporates single-nucleotide polymorphisms; and that also incorporates sequence-based positional information. The position of all markers on our map is corroborated by both genomic sequence and recombination-based data. This specific combination of features maximizes marker inclusion, coverage, and resolution, making this map uniquely suitable as a comprehensive resource for determining genetic map information (order and distances) for any large set of polymorphic markers.

PMID:
15486828
PMCID:
PMC1182151
DOI:
10.1086/426405
[Indexed for MEDLINE]
Free PMC Article

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