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Fertil Steril. 2004 Oct;82(4):857-62.

Insemination with isolated and virologically tested spermatozoa is a safe way for human immunodeficiency type 1 virus-serodiscordant couples with an infected male partner to have a child.

Author information

1
CECOS Midi-Pyrénées and Research Group on Human Fertility; Hôpital Paule de Viguier, Toulouse, France. bujan.l@chu-toulouse.fr

Abstract

OBJECTIVE:

To enable serodiscordant couples to reproduce while minimizing the risk of infecting the female partner and to demonstrate the feasibility of including these couples in an insemination program.

DESIGN:

Prospective follow-up study.

SETTING:

Ambulatory IUIs.

PATIENT(S):

Fifty-six HIV-1-serodiscordant couples with a male infected partner.

INTERVENTION(S):

Sperm cell separation by the gradient density method followed by the swim-up method, virological detection, and IUI after ovarian stimulation.

MAIN OUTCOME MEASURE(S):

Pregnancy rate, HIV-1 test, and p24 antigenemia in women.

RESULT(S):

Two hundred thirteen IUIs were performed, and 37 pregnancies occurred, resulting in 33 births and 2 ongoing pregnancies. Fifty percent of couples have a child. No women were infected.

CONCLUSION(S):

Our study demonstrates the efficiency of an IUI program with prepared and virologically tested spermatozoa in serodiscordant couples with an HIV-1-infected male partner, allowing the couples to have children without transmission of the virus to the female partner.

[Indexed for MEDLINE]

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