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J Invest Dermatol. 2004 Nov;123(5):924-9.

Larval melanocyte regeneration following laser ablation in zebrafish.

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Department of Genetics, Division of Dermatology, Washington University School of Medicine, St Louis, Missouri, USA.


A method to specifically ablate melanocytes in a genetically tractable organism would facilitate the analysis of melanocyte regeneration and regulation. We have demonstrated that a Q-switched neodymium:yttrium-aluminum-garnet dermatology laser kills larval melanocytes in zebrafish. Following melanocyte ablation, new melanocytes regenerate from unpigmented precursors. We show that melanocyte regeneration following laser ablation requires kit receptor tyrosine kinase.

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