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J Invest Dermatol. 2004 Nov;123(5):888-91.

Non-invasive visualization of epidermal responses to injury using a fluorescent transgenic reporter.

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Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA.


We describe transgenic mice in which expression of a reporter, the yellow fluorescent protein (YFP), is locally activated in epidermal cells at sites of injury. YFP is detectable a day after injury; its levels peak within 3 d, and then decline over the subsequent week. Expression is also activated by a chemical irritant, and is suppressed by topical administration of hydrocortisone. These mice permit non-invasive time-lapse monitoring of responses to injury in vivo. They can be used to detect epidermal activation and to test agents that may provoke or attenuate epidermal responses.

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