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Nutr Clin Care. 2004 Apr-Jun;7(2):75-81.

Enzyme replacement as an effective treatment for the common symptoms of complex carbohydrate intolerance.

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  • 1Human Nutrition Program, Rockefeller University, New York, NY 10021, USA.


Complex carbohydrates are an essential part of a healthy diet. However, many people suffer from varying degrees of carbohydrate intolerance, resulting in embarrassing gastrointestinal symptoms and avoidance of these components of a healthy diet. To facilitate awareness and discussion, we propose the phrase "complex carbohydrate intolerance" (CCI) as a broad term to encompass the range of symptoms associated with carbohydrate intolerance. While various treatments offer symptomatic relief, enzyme replacement therapy targets the cause of the problem: an enzyme deficiency. The enzyme, alpha-galactosidase, currently only found in the over-the-counter product, Beano, may be an effective preventative treatment for CCI.

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