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Cell. 2004 Oct 15;119(2):149-51.

A nuclear strike against Listeria--the evolving life of LXR.

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  • 1Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

LXRs are members of the nuclear receptor superfamily and function as master regulators of cholesterol metabolism. In the macrophage, they control cholesterol efflux and inhibit the transcription factor NF-kappaB-mediated proinflammatory responses. In this issue of Cell, discover surprising, protective functions for LXRalpha in innate immunity.

PMID:
15479632
DOI:
10.1016/j.cell.2004.10.003
[PubMed - indexed for MEDLINE]
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