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Arthritis Rheum. 2004 Oct 15;51(5):691-9.

Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating factor 1 correlate with disease activity in ankylosing spondylitis.

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1
University of California Los Angeles, USA.

Abstract

OBJECTIVE:

To assess the usefulness of measuring serum matrix metalloproteinase 3 (MMP-3) and macrophage colony-stimulating factor (M-CSF) in patients with ankylosing spondylitis (AS).

METHODS:

Serum levels of MMP-3 and M-CSF were measured in AS patients who did and did not receive infliximab treatment. These were compared with those of 28 healthy subjects.

RESULTS:

In the group of AS patients not treated with biologics, both M-CSF and MMP-3 correlated with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) values, but not with each other. Logistic regression analysis showed that MMP-3 values were high in those with severely active disease. Infusions of infliximab in AS patients led to a significant decrease in the values of the BASDAI as well as the serum MMP-3, but no change in the serum M-CSF values.

CONCLUSION:

MMP-3 and M-CSF are potentially useful markers of AS disease activity.

PMID:
15478146
DOI:
10.1002/art.20696
[Indexed for MEDLINE]
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