Send to

Choose Destination
J Infect Dis. 2004 Nov 1;190(9):1605-9. Epub 2004 Sep 21.

Persistent paradox of natural history of human T lymphotropic virus type I: parallel analyses of Japanese and Jamaican carriers.

Author information

Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA.


Human T lymphotropic virus type I (HTLV-I) is endemic in southern Japan and the Caribbean, but the incidence of HTLV-I-associated diseases varies across geographic areas. We compared markers of disease pathogenesis among 51 age- and sex-matched HTLV-I carrier pairs from Japan and Jamaica. The mean antibody titer (P=.03) and detection of anti-Tax antibody (P=.002) were higher in Jamaican subjects than in Japanese subjects, but provirus load was similar between the 2 groups (P=.26). The correlation between antibody titer and provirus load was more prominent among Jamaican subjects than among Japanese subjects (P=.06). These findings underscore the differences in host immune response to HTLV-I infection in 2 populations.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center