Send to

Choose Destination
Neurology. 2004 Oct 12;63(7):1286-8.

A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache.

Author information

Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15-10126 Turin, Italy.


Several polymorphisms of the hypocretin/orexin system genes were evaluated in 109 cluster headache patients and 211 controls. The 1246 G>A polymorphism of the gene was significantly different between cases and controls. Homozygosity for the G allele was associated with an increased disease risk (OR: 6.79, 95% CI, 2.25 to 22.99). The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center