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Mol Immunol. 2004 Nov;41(11):1063-75.

Infectious non-self recognition in invertebrates: lessons from Drosophila and other insect models.

Author information

  • 1UPR 9022 CNRS réponse immunitaire des invertébrés, Institut de Biologie Moléculaire et Cellulaire, Université Louis Pasteur, 15 rue René Descartes, 67084 Strasbourg, France. j.royet@ibmc.u-strasbg.fr

Abstract

The vertebrate innate immune system recognizes infectious non-self by employing a set of germline-encoded receptors such as nucleotide-binding oligomerisation domain proteins (NODs) or Toll-like receptors (TLRs). These proteins are involved in the recognition of various microbial-derived molecules, including lipopolysaccharide (LPS), peptidoglycan (PGN) and beta1,3-glucan. Drosophila Toll receptors are not directly dedicated to non-self recognition and insect NOD orthologues have not yet been identified. Studies started more than 20 years ago and conducted on different insect models have identified other receptors on which invertebrate innate systems rely to sense invading microorganisms.

PMID:
15476918
DOI:
10.1016/j.molimm.2004.06.009
[PubMed - indexed for MEDLINE]
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