Format

Send to

Choose Destination
Trends Genet. 2004 Nov;20(11):524-9.

Chromosomal rearrangements and the genomic distribution of gene-expression divergence in humans and chimpanzees.

Author information

1
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader, 80 08003 Barcelona, Catalonia, Spain.

Abstract

The genomic DNA sequences of humans and chimpanzees differ by only 1.24%. Recently, however, substantial differences in gene-expression patterns between the two species have been revealed. In this article, we investigate the genomic distribution of such differences. Besides confirming previous findings about the evolution of sex chromosomes and duplications, we show that chromosomal rearrangements are associated with increased gene-expression differences in the brain and that rearrangements can have both direct and indirect effects on the expression of linked genes. In addition, our results are consistent with a role for some rearrangements in the original speciation events that separated the human and chimpanzee lineages.

PMID:
15475109
DOI:
10.1016/j.tig.2004.08.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center