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Cell. 1992 Mar 6;68(5):989-94.

Requirement for E. coli NusG protein in factor-dependent transcription termination.

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Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032.


The 21 kd NusG protein is essential for E. coli viability. Cells depleted for NusG were defective for factor-dependent transcription termination. Rho-induced polarity in the gal operon and the Rho-dependent lambda tR1 and lambda tL1 terminators were suppressed in NusG-deficient cells. NusG depletion inactivated the phage HK022 Nun termination factor. In contrast, the factor-independent lambda tl terminator was fully active in NusG-depleted cells and could be suppressed by phage lambda N function.

[Indexed for MEDLINE]

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