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Int J Biochem Cell Biol. 2005 Feb;37(2):267-71.

Mcl-1.

Author information

1
Cancer Research UK Oncology Unit, The Somers Cancer Research Building (MP824), University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK.

Abstract

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control, promoting cell survival by interfering at an early stage in a cascade of events leading to release of cytochrome c from mitochondria. Mcl-1 has a short half life and is a highly regulated protein, induced by a wide range of survival signals and also rapidly down regulated during apoptosis. Mcl-1 can also readily be cleaved by caspases during apoptosis to produce a cell death promoting molecule. The multiple levels of control of Mcl-1 expression suggest that Mcl-1 plays a critical role in controlling life and death decisions in response to rapidly changing environmental cues and Mcl-1 is required for embryonic development and the function of the immune system. Expression of Mcl-1 may be useful in informing decision making in the treatment of various cancers, and countering Mcl-1 function may be an attractive therapeutic strategy in malignancy, inflammatory conditions and infectious disease where Mcl-1 may play a major role in suppressing apoptosis.

PMID:
15474972
DOI:
10.1016/j.biocel.2004.04.007
[Indexed for MEDLINE]

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