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FEBS Lett. 2004 Oct 8;576(1-2):245-50.

The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.

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Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.


We have investigated the physiological function of type 2 methionine aminopeptidases (MetAP2) using Caenorhabditis elegans as a model system. A homolog of human MetAP2 was found in the C. elegans genome, which we termed MAP-2. MAP-2 protein displayed methionine aminopeptidase activity and was sensitive to inhibition by fumagillin. Downregulation of map-2 expression by RNAi led to sterility, resulting from a defect in germ cell proliferation. These observations suggest that MAP-2 is essential for germ cell development in C. elegans and that this ubiquitous enzyme may play important roles in a tissue specific manner.

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