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Annu Rev Cell Dev Biol. 2004;20:337-66.

The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium.

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1
Cell and Developmental Biology, University of Dundee Dundee DD1 5EH, Scotland, United Kingdom. i.s.nathke@dundee.ac.uk

Abstract

The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of -catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis. The gut epithelium is uniquely dependent on an intricate balance between a number of fundamental cellular processes including migration, differentiation, adhesion, apoptosis, and mitosis. In this review, I discuss the molecular mechanisms that govern the various functions of APC and their relationship to the role of APC in colon cancer.

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