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Clin Pharmacol Ther. 2004 Oct;76(4):365-70.

No adverse hemodynamic interaction between sildenafil and red wine.

Author information

1
Centre for Cardiovascular Science, The University of Edinburgh, Western General Hospital, United Kingdom. s.j.leslie@ed.ac.uk

Abstract

OBJECTIVE:

Our objective was to investigate the hemodynamic interaction between sildenafil and red wine. Sildenafil citrate (Viagra), a phosphodiesterase type 5 inhibitor, is an effective treatment for male erectile dysfunction that potentiates nitric oxide-mediated vasodilation. Alcohol is a commonly used recreational substance with complex vascular effects, which may, in part, be mediated by nitric oxide. Thus there is potential for an adverse hemodynamic interaction.

METHODS:

Eight healthy men received either 100 mg sildenafil, alcohol (750 mL red wine, 13.5% by volume), or the combination, in a 4-way, double placebo-controlled, randomized crossover study. Blood pressure, heart rate, and cardiac index were measured every 15 minutes up to 180 minutes.

RESULTS:

Results are expressed as mean +/- SEM. Red wine increased cardiac index (by 15% +/- 8%, P = .04) and heart rate (by 27% +/- 5%, P < .0001). Mean arterial pressure initially increased by approximately 5% and then fell by a maximum of approximately 7%. Sildenafil reduced peripheral vascular resistance (by 24% +/- 8%, P = .03) and mean arterial pressure (by 7% +/- 3%, P = .03) with no effect on cardiac index or heart rate.

CONCLUSIONS:

There is no clinically important hemodynamic interaction between sildenafil and alcohol (red wine).

PMID:
15470336
DOI:
10.1016/j.clpt.2004.07.005
[Indexed for MEDLINE]

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