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Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):171-8.

Neurogranin expression in stably transfected N2A cell line affects cytosolic calcium level by nitric oxide stimulation.

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Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore.


To test a cellular effect of rodent neurogranin (Ng) oxidation as compared to Ng phosphorylation, we develop a cell model capable of stable expression of Ng using the Tet-On system, and determine whether Ng oxidation regulates intracellular calcium level. Our results show that Ng oxidation by nitric oxide donor induces an increase of [Ca(2+)](i) in Ng-expressed cells as compared to the control cells without expressing Ng. These results suggest that Ng oxidation plays a significant role in intracellular Ca(2+) homeostasis, essential for the activated signaling networks in learning and memory.

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