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Org Lett. 2004 Oct 14;6(21):3727-30.

Selective amine recognition: development of a chemosensor for dopamine and norepinephrine.

Author information

1
Department of Chemistry, University of Missouri, Columbia, Missouri 65211, USA.

Abstract

[reaction: see text] A boronic acid-containing coumarin aldehyde was designed and synthesized. The sensor binds to catecholamines such as dopamine and norepinephrine by forming an iminium ion with the amine as well as a boronate ester with the catechol. An internal hydrogen bond produces a colorimetric response to these analytes with good selectivity for catecholamines over simple amines. The fluorescence of the sensor is quenched by the catechol.

PMID:
15469334
DOI:
10.1021/ol048625f
[Indexed for MEDLINE]

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