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Otolaryngol Head Neck Surg. 2004 Oct;131(4):342-50.

Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo-control trial.

Author information

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, OH 45267-0528, USA. David.Steward@uc.edu

Abstract

OBJECTIVE:

To determine the efficacy of proton-pump inhibitor (PPI) therapy for chronic laryngo-pharyngitis treated with lifestyle modification.

STUDY DESIGN AND METHODS:

Double-blind, randomized trial comparing two-month Rabeprazole (20 mg b.i.d.) to placebo control.

RESULTS:

Compared to baseline, both PPI and control patients had significant improvement in total reflux symptoms (P = 0.002 and P = 0.03 respectively), with significant improvement in "laryngo-pharyngeal" but not "typical" reflux symptoms. No significant difference was noted for change in reflux symptoms between PPI-treated and control patients (P = 0.44). Significant global improvement was noted by 50% of control and 53% of PPI-treated patients (P = 1.0). No significant differences were noted within or between treatment groups for change in health status or videostrobolaryngoscopy grade. Lifestyle modification compliance correlated significantly with global improvement.

CONCLUSION:

Compared to baseline, lifestyle modification for 2 months significantly improved chronic laryngo-pharyngitis symptoms. When compared to control, treatment with a PPI failed to demonstrate significantly greater improvement in reflux symptoms, health status, or laryngeal appearance.

PMID:
15467597
DOI:
10.1016/j.otohns.2004.03.037
[PubMed - indexed for MEDLINE]
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