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Am J Obstet Gynecol. 2004 Sep;191(3):847-55.

Cardiovascular and renal disease in the adolescent guinea pig after chronic placental insufficiency.

Author information

1
Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia. tabris@unimelb.edu.au

Abstract

OBJECTIVE:

The aim of this study was to determine the long-term effects of chronic placental insufficiency on the metabolic state and organ structure in the fetal and adolescent guinea pig.

STUDY DESIGN:

The maternal uterine artery was ligated at day 28-30 to reduce placental function and restrict fetal growth. Whole body and tissue weights and plasma metabolites were determined at 60 days of gestation and 8 weeks of age; tissue structure was determined at the latter age in restricted and control offspring.

RESULTS:

Fetal growth restriction increased fibrosis in the heart and kidneys (P < .05), increased aortic wall thickening (P < .01), reduced the number of glomeruli in the kidneys (P < .05), and increased the plasma urea and chloride in adolescent offspring.

CONCLUSION:

This study demonstrates that diseases in the heart, aorta, and kidneys that result from an adverse prenatal environment are evident at adolescence and may contribute to subsequent adult disease.

PMID:
15467552
DOI:
10.1016/j.ajog.2004.01.050
[Indexed for MEDLINE]

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