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Cell Cycle. 2004 Sep;3(9):1133-7. Epub 2004 Sep 5.

The life cycle of C-myc: from synthesis to degradation.

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Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland 97239, USA.


The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled. c-Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a sophisticated and complex signaling pathway that controls the life cycle of c-Myc from protein synthesis to ubiquitin-mediated degradation. The pathway involves Ras-activated kinases, the Pin1 prolyl isomerase, the PP2A phosphatase and a series of c-Myc phosphorylation and dephosphorylation events that control its stability.

[Indexed for MEDLINE]

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