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Arch Gen Psychiatry. 2004 Oct;61(10):997-1004.

The effects of pharmacologically induced hypogonadism on mood in healthy men.

Author information

1
Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1276, USA. schmidtp@intra.nimh.nih.gov

Abstract

BACKGROUND:

The effects of declining androgen secretion on mood regulation and the potential psychotropic efficacy of androgen replacement in men are largely undetermined.

OBJECTIVE:

To examine the effects on mood of the acute suppression of testosterone secretion.

DESIGN:

A double-blind, placebo-controlled, crossover (self-as-own-control) study.

SETTING:

An ambulatory care clinic in a research hospital.

PARTICIPANTS:

Thirty-one healthy adult men with no history of psychiatric illness or substance or anabolic steroid abuse.

INTERVENTIONS:

Men received depot leuprolide acetate (Lupron, 7.5 mg intramuscularly) every 4 weeks for 3 months. After the first month of Lupron alone, all men received (in addition to Lupron) testosterone enanthate (200 mg intramuscular) or placebo (sesame oil as color-matched vehicle) every 2 weeks for 1 month each in a crossover design. The order of administration of testosterone and placebo was randomly assigned and counterbalanced.

MAIN OUTCOME MEASURES:

Mood and behavior rating scores (self-report and rater administered).

RESULTS:

With the exceptions of hot flushes, libido, and the feeling of being emotionally charged, none of the symptoms measured showed a significant difference across eugonadal, Lupron plus placebo, and Lupron plus testosterone conditions. Despite the absence of a uniform effect of Lupron plus placebo on mood, 3 men experienced clinically relevant mood symptoms during this induced hypogonadal condition. High baseline levels of sexual functioning predicted the greatest decline in sexual function during Lupron plus placebo.

CONCLUSIONS:

These data, the first to describe the effects on mood of induced hypogonadism in healthy young men, suggest that short-term hypogonadism is sufficient to precipitate depressive symptoms in only a small minority of younger men. The predictors of this susceptibility remain to be determined.

PMID:
15466673
DOI:
10.1001/archpsyc.61.10.997
[Indexed for MEDLINE]

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