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Control Clin Trials. 2004 Oct;25(5):493-501.

The utility of partial cross-over designs in early phase randomized prevention trials.

Author information

1
University at Buffalo, Department of Biostatistics, Farber Hall Room 249A, 3435 Main St., Buffalo, NY 14214-3000, USA.

Abstract

In this note, we outline the benefits of a partial cross-over design for a class of experiments where the interest is the cumulative effect of dose versus placebo. The goal of our design strategy is to answer several complex question efficiently in a phase II setting with a minimal number of assumptions with an eye towards planning a phase III study.

PMID:
15465618
DOI:
10.1016/j.cct.2004.07.005
[Indexed for MEDLINE]

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