Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurosci Biobehav Rev. 2004 Sep;28(5):497-505.

The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory.

Author information

1
Department of Psychology, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. rob.hughes@canterbury.ac.nz

Abstract

Because of its reliance on memory, the tendency for rats, mice and other animals to alternate successive choices of T- or Y-maze arms has assumed considerable popularity in pharmacological studies of spatial memory as a quick and simple measure of retention that avoids the need for extensive training and the use of conventional reinforcers. Two forms of this tendency have been utilized, namely two-trial and continuous spontaneous alternation behavior (SAB). However, as the behavior can also reflect drug-related changes in sensory/attentional, motivational and performance processes, SAB should not be unquestionably accepted as a measure of memory alone. While assessments of post-acquisition drug effects on longer term memory may be possible through the appropriate timing of drug administration, this is more problematic if SAB is used as a measure of shorter term memory. Even though SAB can be a useful index of responsiveness to novelty, its value as a measure of retention is less certain. In this latter respect, a possible alternative to SAB testing might be the recently developed form of the related procedure, responsiveness to change.

PMID:
15465137
DOI:
10.1016/j.neubiorev.2004.06.006
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center