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Eur J Med Chem. 2004 Oct;39(10):873-7.

Synthesis and biological activity of new derivatives of 3-(3,4-diaryl-1,2,4-triazole-5-yl)propenoic acid.

Author information

1
Department of Organic Chemistry, Medical University, Jagiellońska 13, 85-067 Bydgoszcz, Poland. modzel@panaceum.am.lublin.pl

Abstract

New 3-(3,4-diaryl-1,2,4-triazole-5-yl)propenoic acid derivatives (8-14) were synthesized by condensation of N(3)-substituted amidrazones (1-7) with maleic anhydride. Molecular structure of obtained compounds was confirmed by an elemental analysis, IR and (1)H NMR spectra, and the X-ray crystallography for compound 11. The influence of the compound 9 on the central nervous system (CNS) of mice in some behavioural test was examined. The investigated compound showed anticonvulsive activity and potent antinociceptive action.

PMID:
15464621
DOI:
10.1016/j.ejmech.2004.07.002
[Indexed for MEDLINE]
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